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Targeted Allele Detail
Symbol: Gata6tm1Msp
Name: GATA binding protein 6; targeted mutation 1, Michael S Parmacek
MGI ID: MGI:2177785
Synonyms: Gata6-
Gene: Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:51304
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5, which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:51304)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:  9 strains or lines available
Original:  J:51304 Morrisey EE, et al., GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 1998 Nov 15;12(22):3579-90
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory