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Targeted Allele Detail
Symbol: Il11ra1tm1Gos
Name: interleukin 11 receptor, alpha chain 1; targeted mutation 1, Achim Gossler
MGI ID: MGI:2177774
Synonyms: Il11ra1TgH(PGKneo)7Gos, IL-11RalphaTgH(PGK-neo)
Gene: Il11ra1  Location: Chr4:41699989-41769474 bp, + strand  Genetic Position: Chr4, 21.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:48920
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting event resulted in the insertion of a neomycin resistance gene into intron 8, followed by a truncated, promoterless Il11ra1 gene lacking exons 2-13. Northern blot experiments on RNA derived from kidney of homozygous mice demonstrated that an aberrant transcript was produced from this allele. It was a size consistent with the splicing around the neo cassette to produce a transcript that contains exon 1-8 fused to exons 2-13. Western blot analysis on kidney extracts confirmed that an aberrantly sized protein was expressed from this allele, although at lower levels than Il11ra1tm2Gos. (J:48920)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il11ra1 Mutation:  10 strains or lines available
Original:  J:48920 Bilinski P, et al., Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998 Jul 15;12(14):2234-43
All:  2 reference(s)

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last database update
MGI 6.06
The Jackson Laboratory