Egr1^tm1The
Targeted Allele Detail

Summary

• Symbol: Egr1^tm1The
• Name: early growth response 1; targeted mutation 1, Takao K Hensch
• MGI ID: MGI:2177610
• Synonyms: egr1 KO
• Gene: Egr1 Location: Chr18:34994260-34998009 bp, + strand Genetic Position: Chr18, 18.76 cM, cytoband C/D
• Alliance: Egr1^tm1The page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73383
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: insertion of a neomycin resistance cassette disrupted the coding sequence upstream of the zinc finger domain. Immunohistochemical studies of visual cortex did not detect protein in homozygous mutant mice. (J:73383)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr1 Mutation: 19 strains or lines available

References

• Original: J:73383 Mataga N, et al., Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001 Dec 15;21(24):9724-32
• All: 1 reference(s)