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Targeted Allele Detail
Symbol: Egr1tm1The
Name: early growth response 1; targeted mutation 1, Takao K Hensch
MGI ID: MGI:2177610
Synonyms: egr1 KO
Gene: Egr1  Location: Chr18:34861207-34864956 bp, + strand  Genetic Position: Chr18, 18.76 cM, cytoband C/D
Germline Transmission:  Earliest citation of germline transmission: J:73383
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsinsertion of a neomycin resistance cassette disrupted the coding sequence upstream of the zinc finger domain. Immunohistochemical studies of visual cortex did not detect protein in homozygous mutant mice. (J:73383)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egr1 Mutation:  6 strains or lines available
Original:  J:73383 Mataga N, et al., Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001 Dec 15;21(24):9724-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory