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Alpltm1(cre)Nagy
Targeted Allele Detail
Nomenclature
Symbol: Alpltm1(cre)Nagy
Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Andras Nagy
MGI ID: MGI:2177588
Synonyms: Alpl-cre, TNAPCre, TNAP-Cre, TNAP/Cre
Gene: Alpl  Location: Chr4:137741733-137796384 bp, - strand  Genetic Position: Chr4, 70.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60934
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre gene followed by a neomycin gene was inserted into exon 6 of the gene. This allele expresses Cre recombinase in primordial germ cells. (J:60934)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Alpl     Summary of all recombinase alleles driven by Alpl. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 27 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Alpl Mutation:  343 strains or lines available
References
Original:  J:60934 Lomeli H, et al., Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis. 2000 Feb;26(2):116-7
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory