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Gata1tm2Sho
Targeted Allele Detail
Nomenclature
Symbol: Gata1tm2Sho
Name: GATA binding protein 1; targeted mutation 2, Stuart Orkin
MGI ID: MGI:2177586
Synonyms: GATA-1low, neodeltaHS, neo deltaHS
Gene: Gata1  Location: ChrX:7959260-7976682 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41605
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin selection cassette replaced the "IT" and DNAseI hypersensitive region of the promoter. RT-PCR experiments demonstrated that this mutation resulted in the loss of expression in megakaryocytes and fetal liver but not in erythroid cells. (J:41605)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  42 strains or lines available
References
Original:  J:41605 Shivdasani RA, et al., A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory