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Targeted Allele Detail
Symbol: Cftrtm2Bay
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 2, Baylor College of Medicine
MGI ID: MGI:2177532
Synonyms: cftrm2Bay
Gene: Cftr  Location: Chr6:18170687-18322768 bp, + strand  Genetic Position: Chr6, 8.1 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:15244
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn insertion vector that contained a mutated exon 3 and a neomycin selection cassette was inserted into intron 2 of the gene. The mutated exon 3 contained an oligonucleotide that introduced stop codons in all three reading frames. (J:15244)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cftr Mutation:  13 strains or lines available
Original:  J:15244 O'Neal WK, et al., A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. Hum Mol Genet. 1993 Oct;2(10):1561-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory