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Foxa2tm1Khk
Targeted Allele Detail
Nomenclature
Symbol: Foxa2tm1Khk
Name: forkhead box A2; targeted mutation 1, Klaus H Kaestner
MGI ID: MGI:2177337
Synonyms: Foxa2flox, Foxa2loxP, HNF3betaflox
Gene: Foxa2  Location: Chr2:148042877-148046969 bp, - strand  Genetic Position: Chr2, 73.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63039
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted into intron 2 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted into intron 3. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice, leaving exon 2 flanked by loxP sites in the final allele. (J:63039)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxa2 Mutation:  12 strains or lines available
References
Original:  J:63039 Sund NJ, et al., Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory