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Targeted Allele Detail
Symbol: Brca2tm1Cbl
Name: breast cancer 2, early onset; targeted mutation 1, Chester Beatty Laboratories
MGI ID: MGI:2177226
Synonyms: Brca2Tr2014
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:44386
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 11 at position 6038. RT-PCR analysis on RNA derived from homozygous animals demonstrated that a partial transcript is made from this allele. Western blot analysis confirmed that no protein with an intact carboxy-terminus was expressed from this allele, but the authors do not rule out the possiblilty that a partial product could be made. (J:44386)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  76 strains or lines available
Original:  J:44386 Connor F, et al., Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet. 1997 Dec;17(4):423-30
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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