About   Help   FAQ
Targeted Allele Detail
Symbol: Atp12atm1Ges
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide; targeted mutation 1, Gary E Shull
MGI ID: MGI:2177160
Synonyms: cHKA -
Gene: Atp12a  Location: Chr14:56602525-56626007 bp, + strand  Genetic Position: Chr14, 28.19 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:45707
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA nenomycin selection cassette was inserted into exon 20. Northern blot and RT-PCR analysis on RNA derived from colon of homozygous mice demonstrated that aberrantly spliced transcripts were produced from this allele, but none of these produced a functional message. (J:45707)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp12a Mutation:  43 strains or lines available
Original:  J:45707 Meneton P, et al., Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice. J Clin Invest. 1998 Feb 1;101(3):536-42
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory