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Atp12atm1Ges
Targeted Allele Detail
Nomenclature
Symbol: Atp12atm1Ges
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide; targeted mutation 1, Gary E Shull
MGI ID: MGI:2177160
Synonyms: cHKA -
Gene: Atp12a  Location: Chr14:56365068-56388551 bp, + strand  Genetic Position: Chr14, 28.19 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45707
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA nenomycin selection cassette was inserted into exon 20. Northern blot and RT-PCR analysis on RNA derived from colon of homozygous mice demonstrated that aberrantly spliced transcripts were produced from this allele, but none of these produced a functional message. (J:45707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp12a Mutation:  30 strains or lines available
References
Original:  J:45707 Meneton P, et al., Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice. J Clin Invest. 1998 Feb 1;101(3):536-42
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory