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Targeted Allele Detail
Symbol: Nf1tm1.1Par
Name: neurofibromin 1; targeted mutation 1.1, Luis F Parada
MGI ID: MGI:2176764
Synonyms: Nf1-, Nf1delta
Gene: Nf1  Location: Chr11:79339693-79581612 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Germline Transmission:  Earliest citation of germline transmission: J:68558
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Nf1tm1Par. Exons 31 and 32 were deleted via Cre mediated recombination. This was achieved by mating mice carrying the NF1tm1Par mutation to mice carrying Egr2tm2(Cre)Pch (strain 129S2/SvPas). This deletion is heritable, and is transmitted through the germ line. (J:68558)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  92 strains or lines available
Original:  J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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