About   Help   FAQ
Nf1tm1.1Par
Targeted Allele Detail
Nomenclature
Symbol: Nf1tm1.1Par
Name: neurofibromin 1; targeted mutation 1.1, Luis F Parada
MGI ID: MGI:2176764
Synonyms: Nf1-, Nf1delta
Gene: Nf1  Location: Chr11:79339693-79581612 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68558
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Nf1tm1Par. Exons 31 and 32 were deleted via Cre mediated recombination. This was achieved by mating mice carrying the NF1tm1Par mutation to mice carrying Egr2tm2(Cre)Pch (strain 129S2/SvPas). This deletion is heritable, and is transmitted through the germ line. (J:68558)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  85 strains or lines available
References
Original:  J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory