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Il4tm1Lky
Targeted Allele Detail
Nomenclature
Symbol: Il4tm1Lky
Name: interleukin 4; targeted mutation 1, Richard M Locksley
MGI ID: MGI:2176574
Synonyms: 4get, 4 get, 4-get
Gene: Il4  Location: Chr11:53503287-53509492 bp, - strand  Genetic Position: Chr11, 31.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75415
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked neomycin cassette followed by an internal ribosomal entry site (IRES) and an EGFP gene was inserted into sequences corresponding to the 3' untranslated region in exon 4. The neomycin cassette was removed by Cre mediated germline recombination in chimeric mice to generate the final allele. These mice express green fluorescent protein under the control of the Il4 promoter. (J:75415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  33 strains or lines available
References
Original:  J:75415 Mohrs M, et al., Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 2001 Aug;15(2):303-11
All:  145 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory