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Targeted Allele Detail
Symbol: Aregtm1Dle
Name: amphiregulin; targeted mutation 1, David C Lee
MGI ID: MGI:2176531
Synonyms: AR-
Gene: Areg  Location: Chr5:91139599-91148432 bp, + strand  Genetic Position: Chr5, 44.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:54980
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 3 and 4, which encode three disulfide loops, the heparin binding region and the transmembrane domain of the precursor protein. Northern blot analysis on RNA derived from stomach and skin of homozygous mice demonstrated that a smaller transcript is produced from this allele. RT-PCR and sequencing analysis confirmed the loss of coding sequences from this transcript. (J:54980)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Areg Mutation:  7 strains or lines available
Original:  J:54980 Luetteke NC, et al., Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development. 1999 Jun;126(12):2739-50
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory