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Targeted Allele Detail
Symbol: Ptpn11tm1Rbn
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Daniel U Rabin
MGI ID: MGI:2176526
Synonyms: syp
Gene: Ptpn11  Location: Chr5:121130533-121191397 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:35137
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 2 and flanking sequences. Western blot analysis on lyastes prepared from various tissues of heterozygous mice confirmed that protein levels were reduced by 40-50% in all tissue examined. (J:35137)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  21 strains or lines available
The ES cell line used was G1 (Bayer Corp., unpublished). This appears to have been derived from an unspecified subline of 129.

Original:  J:35137 Arrandale JM, et al., Insulin signaling in mice expressing reduced levels of Syp. J Biol Chem. 1996 Aug 30;271(35):21353-8
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory