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Runx2tm1Kish
Targeted Allele Detail
Nomenclature
Symbol: Runx2tm1Kish
Name: runt related transcription factor 2; targeted mutation 1, Tadamitsu Kishimoto
MGI ID: MGI:2176466
Synonyms: Cbfa1-, Runx2-, Runx2-deltaC, Runx2tm1Tki
Gene: Runx2  Location: Chr17:44495987-44814797 bp, - strand  Genetic Position: Chr17, 21.33 cM
Calvaria and clavicle abnormalities in Gsk3btm1Jrw/Gsk3b+, Runx2tm1Kish/Runx2+, and Gsk3btm1Jrw/Gsk3b+ Runx2tm1Kish/Runx2+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40783
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 76 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx2 Mutation:  2 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hypothyroidism, Congenital (J:162258)

References
Original:  J:40783 Komori T, et al., Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts [see comments]. Cell. 1997 May 30;89(5):755-64
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory