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Marcksl1tm1Stl
Targeted Allele Detail
Nomenclature
Symbol: Marcksl1tm1Stl
Name: MARCKS-like 1; targeted mutation 1, Susumu Tonegawa
MGI ID: MGI:2176278
Synonyms: F52-deficient
Gene: Marcksl1  Location: Chr4:129513581-129515985 bp, + strand  Genetic Position: Chr4, 63.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32127
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the entire coding region of the gene. Northern blot analysis of brain RNA derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:32127)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Marcksl1 Mutation:  1 strain or line available
References
Original:  J:32127 Wu M, et al., Neural tube defects and abnormal brain development in F52-deficient mice. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2110-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory