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Targeted Allele Detail
Symbol: Smotm2Amc
Name: smoothened, frizzled class receptor; targeted mutation 2, Andrew P McMahon
MGI ID: MGI:2176256
Synonyms: Smoc, Smof, Smofl, Smoflox
Gene: Smo  Location: Chr6:29735503-29761365 bp, + strand  Genetic Position: Chr6, 12.36 cM, cytoband A3.3
Intestinal mesenchymal proliferation and expansion are affected in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:73071
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change, Reporter)
Mutation:    Insertion
Mutation detailsTwo loxP sites and an frt-flanked neomycin resistance cassette were inserted flanking ~400 bp of the first coding exon 1 from 44 bp upstream through 358 bp downstream of the translation initiation codon. A tau-LacZ gene was also inserted 3' to the neomycin resistance gene. (J:73071)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 142 assay results
In Structures Affected by this Mutation: 63 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smo Mutation:  9 strains or lines available
Original:  J:73071 Long F, et al., Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec;128(24):5099-108
All:  148 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory