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Mapk9tm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Mapk9tm1Flv
Name: mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell
MGI ID: MGI:2176243
Synonyms: Jnk2-, Jnk2 KO
Gene: Mapk9  Location: Chr11:49846753-49886421 bp, + strand  Genetic Position: Chr11, 29.96 cM, cytoband B1.2
Abnormal epidermis of adult Mapk8tm1Flv/Mapk8tm1Flv and Mapk9tm1Flv/Mapk9tm1Flv mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50628
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing three coding exons containing sequences required for protein kinase activity. RT-PCR analysis on RNA derived from thymus of homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on brain, thymocyte and T cells derived from homozygous mice confirmed that no protein was expressed from this allele. (J:50628)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk9 Mutation:  16 strains or lines available
References
Original:  J:50628 Yang DD, et al., Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity. 1998 Oct;9(4):575-85
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory