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Tg(Ins2-cre)25Mgn
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-cre)25Mgn
Name: transgene insertion 25, Mark A Magnuson
MGI ID: MGI:2176227
Synonyms: Ins2cre, Ins-Cre, M line, RIP2-cre, RIP2Cre, Rip-cre, RIPCre, [RIP]-Cre, RIP Cre, TgN(ins2-Cre)25Mgn
Transgene: Tg(Ins2-cre)25Mgn  Location: Chr7:62991157-63008557 bp  Genetic Position: Chr7, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutations:    Duplication, Insertion
 
Mutation detailsThis transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the rat insulin promoter (Ins2), which is active in pancreatic beta cells and in neurons of the hypothalamus. 9 copies of the transgene are estimated to be present. Transgene insertion occurred on Chr 7, causing a 17400 bp duplication. (J:51826, J:253473)
Recombinase
activity
Activity:
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Driver: Ins2     Summary of all recombinase alleles driven by Ins2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:  226 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory