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QTL Variant Detail
QTL variant: Gasa3BALB/cCrSlc
Name: gastritis type A susceptibility locus 3; BALB/cCrSlc
MGI ID: MGI:2176196
QTL: Gasa3  Location: Chr6:105982366-105982564 bp  Genetic Position: Chr6, cM position of peak correlated region/allele: 48.93 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  BALB/cCrSlc
Allele Type:    QTL
Mutation:    Undefined
    Susceptibility to autoimmune gastritis is conferred in the heterozygous state. (J:75277)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures

Mapping and Phenotype information for this QTL, its variants and associated markers


F2 animals from a cross between BALB/cCrSlc (susceptible) and C57BL/6 (resistant) strains were used to screen for minor loci contributing to susceptibility gastritis type A. Only animals fixed at Gasa1 or Gasa2 were used in the segregation analysis. 135 loci were screened at an average density of 15 cM. A locus on mouse Chromosome 6 reached significant linkage at approximately 44 cM and was designated Gasa3 (gastritis type A susceptibility locus 3). Gasa3 spans 41.5 cM - 46.3 cM on chromosome 6 with a LOD score of 4.7 at D6Mit149. Animals heterozygous as Gasa3 exhibit susceptibility to autoimmune gastritis. A locus on mouse Chromosome 17 reached suggestive significance near the region of the H2 locus and was designated Gasa4. Gasa4 was confirmed in a cross between BALB/cCrSlc and a congenic line carrying C57BL/10-derived DNA from D17Mit62 to D17Mit177 encompassing the H2 locus. Heterozygosity as Gasa4 confers increased penetrance of autoimmune gastritis in day 3 thymectomized mice. Gasa4 appears to interact with Gasa2. Heterozygosity at Gasa4 and homozygosity at Gasa2 for BALB/cCrSlc-derived alleles confers maximum increase in disease penetrance.

Original:  J:75277 Silveira PA, et al., Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses. Immunogenetics. 2001 Dec;53(9):741-50
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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