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Adcyap1tm1Eid
Targeted Allele Detail
Nomenclature
Symbol: Adcyap1tm1Eid
Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Lee E Eiden
MGI ID: MGI:2159730
Synonyms: PACAP-
Gene: Adcyap1  Location: Chr17:93199422-93205485 bp, + strand  Genetic Position: Chr17, 60.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73702
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the ORF. Immunohistochemical studies of hypothalamus and IML of spinal cord did not detect protein in homozygous mice. Quantitative RT-PCR studies of hypothalamus and spinal cord did not detect mRNA in homozygous mutant mice. (J:73702)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:  13 strains or lines available
References
Original:  J:73702 Hamelink C, et al., Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):461-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory