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Targeted Allele Detail
Symbol: Tacc3tm1Jni
Name: transforming, acidic coiled-coil containing protein 3; targeted mutation 1, James N Ihle
MGI ID: MGI:2159700
Gene: Tacc3  Location: Chr5:33658128-33672203 bp, + strand  Genetic Position: Chr5, 17.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:74762
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette is inserted into the third exon and is predicted to disrupt splicing. Failure to detect gene specific RNA and protein in fetal livers or total embryo extracts derived from homozygous animals confirmed the null nature of this allele. (J:74762)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacc3 Mutation:  11 strains or lines available
Original:  J:74762 Piekorz RP, et al., The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 2002 Feb 15;21(4):653-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory