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Inpp5btm2.1Nbm
Targeted Allele Detail
Summary
Symbol: Inpp5btm2.1Nbm
Name: inositol polyphosphate-5-phosphatase B; targeted mutation 2.1, Robert L Nussbaum
MGI ID: MGI:2159620
Synonyms: Inpp5btr
Gene: Inpp5b  Location: Chr4:124635643-124695304 bp, + strand  Genetic Position: Chr4, 57.89 cM, cytoband D2
Alliance: Inpp5btm2.1Nbm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73678
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Inpp5btm2Nbm in which Cre-mediated recombination in vivo under control of an EIIa promoter excised both the neomycin resistance cassette and exon 15 in the germline. Northern blot analysis using a 3' UTR probe did not detect either transcript in testis from homozygous mutant mice. RT-PCR analysis of testis with primers flanking exon 15 detected a deletion of 137 bp in the RNA transcribed by this allele. (J:73678)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Inpp5b Mutation:  57 strains or lines available
References
Original:  J:73678 Hellsten E, et al., Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol. 2001 Dec 15;240(2):641-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory