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Targeted Allele Detail
Symbol: Cpb2tm1Mng
Name: carboxypeptidase B2 (plasma); targeted mutation 1, Mariko Nagashima
MGI ID: MGI:2159468
Synonyms: TAFI-
Gene: Cpb2  Location: Chr14:75242287-75283555 bp, + strand  Genetic Position: Chr14, 39.73 cM, cytoband D2
Germline Transmission:  Earliest citation of germline transmission: J:73713
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced half of exon 8 and all of exon 9, sequences that encode zinc and substrate binding sites. RT-PCR analysis using primers that span the entire coding region detected a truncated transcript in liver from homozygous mutant mice. Western blot analysis using polyclonal antibodies raised against a peptide encoded by exon 5 did not detect protein in plasma from homozygous mutant mice. (J:73713)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpb2 Mutation:  13 strains or lines available
Original:  J:73713 Nagashima M, et al., Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life. J Clin Invest. 2002 Jan;109(1):101-10
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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