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Pcpila3C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Pcpila3C57BL/6J
Name: PCP induced locomotor activity 3; C57BL/6J
MGI ID: MGI:2159385
QTL: Pcpila3  Location: unknown  Genetic Position: Chr15, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased PCP-induced locomotor activity compared to DBA/2J. (J:36714)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36714

26 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains were analyzed for QTLs linked to PCP- and amphetamine-induced activation of locomotor activity. Parental strain C57BL/6J exhibits greater locomotor behavior following PCP administration compared to DBA/2J. Loci affecting PCP induced locomotor activity (Pcpila) mapped to 106.3 cM on mouse Chromosome 1 (Pcpila1), 2 cM on mouse Chromosome 14 (Pcpila2), and 38.2 cM on mouse Chromosome 15 (Pcpila3). C57BL/6J-derived alleles confer increased PCP induced locomotor activity at all mapped loci.

References
Original:  J:36714 Alexander RC, et al., Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice. Neuropsychopharmacology. 1996 Nov;15(5):484-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory