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Targeted Allele Detail
Symbol: Casp2tm1Yuan
Name: caspase 2; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159368
Gene: Casp2  Location: Chr6:42264985-42282508 bp, + strand  Genetic Position: Chr6, 20.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:47601
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 1.65 kb genomic fragment containing sequences that encode part of the active site of the protein and other essential regions. RT-PCR analysis on spleen mRNA derived from homozygous mice demonstrated that no detectable transcript is expressed from this allele, and western blot analysis on lysates derived from various tissues of homozygous mice confirmed that no detectable protein was encoded. (J:47601)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp2 Mutation:  10 strains or lines available
Original:  J:47601 Bergeron L, et al., Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 1998 May 1;12(9):1304-14
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory