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Cflartm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Cflartm1Mak
Name: CASP8 and FADD-like apoptosis regulator; targeted mutation 1, Tak W Mak
MGI ID: MGI:2159361
Synonyms: casper-
Gene: Cflar  Location: Chr1:58711508-58758884 bp, + strand  Genetic Position: Chr1, 29.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63049
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing part of the first exon, including the start codon. Northern blot analysis on RNA derived from embryonic fibroblasts of homozygous mice demonstrated that no detectable transcript is expressed from this allele. (J:63049)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cflar Mutation:  10 strains or lines available
References
Original:  J:63049 Yeh WC, et al., Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity. 2000 Jun;12(6):633-42
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory