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Targeted Allele Detail
Symbol: Tektm1Dmt
Name: endothelial-specific receptor tyrosine kinase; targeted mutation 1, Daniel J Dumont
MGI ID: MGI:2159357
Synonyms: tekdeltasp, Tie2-
Gene: Tek  Location: Chr4:94739289-94874976 bp, + strand  Genetic Position: Chr4, 43.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:20015
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced sequences in exon 1, which encode the translation start site and the first 17 amino acids of the protein. (J:20015)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tek Mutation:  49 strains or lines available
Original:  J:20015 Dumont DJ, et al., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994 Aug 15;8(16):1897-909
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory