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Targeted Allele Detail
Symbol: Gpc3tm1Snd
Name: glypican 3; targeted mutation 1, Scott Saunders
MGI ID: MGI:2159355
Synonyms: Gpc3tm108Sau
Gene: Gpc3  Location: ChrX:52272426-52613950 bp, - strand  Genetic Position: ChrX, 28.74 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:64330
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced genomic sequences corresponding to the transcriptional and translational start sites, and encoding the signal peptide and first 33 amino acids of the mature protein. Western blot analysis on purified proteoglycan extracts derived from E16.5 liver of male hemizygous mice confirmed that no detectable protein is produced from this allele. (J:64330)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpc3 Mutation:  16 strains or lines available
Original:  J:64330 Paine-Saunders S, et al., glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000 Sep 1;225(1):179-87
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory