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Bis1C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Bis1C57BL/6J
Name: beta-carboline-induced seizures 1; C57BL/6J
MGI ID: MGI:2159255
QTL: Bis1  Location: Chr4:137137122-137137225 bp  Genetic Position: Chr4, cM position of peak correlated region/allele: 69.44 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
This allele confers resistance to beta-CCM (methyl beta-carboline-3-carboxylate) induced myoclonic seizures compared to A/J.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:28058

The authors analyzed six mouse strains for susceptibility to (beta)-carboline induced seizures, of which only two gave significant results. In one strain, Je/LeGnc, theauthors detected an association between Bis1 and je. Analysis of (C3XtEso/Gnc x Je/LeGnc)F1 backcross and intercross progeny confirmed the mapping of Bis1 to within ~3.1 cM of je on mouse Chromsome 4.

J:54925

The authors examined the gentic basis of differences in seizure behaviour using a GABAa receptor agoinst beta CCM (methyl beta-carboline-3 carboxylate). A/J mice are more susceptible to beta-CCM induced myoclonic seizures than C57BL/6J mice in both latency to seizure and proportion of tested mice that seized. The previously identified Bis1 QTL was confirmed in a subsequent backcross population (n = 223), D4Mit68 on distal Chromosome 4 is associated with seizure susceptibility (chi square = 10.3; p<0.0012; n = 217) and seizure latency. A LOD score = 2.88 was assigned to this locus and it accounted for 6-9% of the phenotypic variance for this seizure trait. The best-fitting logistic regression model suggests that the C57BL/6J allele at the D4Mit68 locus increased the likelihood of resistance to seizures at 23 fold. Candidate genes in this region include Htr1da, Htr1db and Slc9a1.

References
Original:  J:54925 Gershenfeld HK, et al., Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. J Neurosci. 1999 May 15;19(10):3731-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory