Atoh7^tm1Gla
Targeted Allele Detail

Summary

• Symbol: Atoh7^tm1Gla
• Name: atonal bHLH transcription factor 7; targeted mutation 1, Tom Glaser
• MGI ID: MGI:2159015
• Synonyms: Math5-, Math5-lacZ
• Gene: Atoh7 Location: Chr10:62935564-62937059 bp, + strand Genetic Position: Chr10, 32.54 cM
• Alliance: Atoh7^tm1Gla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the sequences encoding the bHLH domain. In addition, a lacZ gene was inserted in frame into the beginning of the coding sequences. A beta-galactosidase fusion protein was expressed from this allele under the control of the endogenous promoter. RT-PCR analysis confirmed that no transcript containing Atoh7 coding sequences is produced from this allele. (J:70746)

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atoh7 Mutation: 9 strains or lines available

References

• Original: J:70746 Brown NL, et al., Math5 is required for retinal ganglion cell and optic nerve formation. Development. 2001 Jul;128(13):2497-508
• All: 25 reference(s)