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Targeted Allele Detail
Symbol: Anxa7tm1Pll
Name: annexin A7; targeted mutation 1, Harvey B Pollard
MGI ID: MGI:2159005
Synonyms: anx7 -
Gene: Anxa7  Location: Chr14:20455261-20480133 bp, - strand  Genetic Position: Chr14, 11.53 cM
Metastatic lymphosarcoma of the thymus in Anxa7tm1Pll/Anxa7+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:58572
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exon 6. Western blot analysis on pancreatic tissue lysates of homozygous mice confirmed that levels of the encoded protein were reduced in heterozygotes compared to wild-type. (J:58572)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anxa7 Mutation:  17 strains or lines available
Original:  J:58572 Srivastava M, et al., Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13783-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory