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Targeted Allele Detail
Symbol: Sema3atm1.1Tyag
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1.1, Takeshi Yagi
MGI ID: MGI:2158944
Synonyms: Sema3a-, semaphorin III/D null
Gene: Sema3a  Location: Chr5:13175381-13652533 bp, + strand  Genetic Position: Chr5, 4.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:43443
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was generated from Sema3atm1Tyag by transient cre expression in TT-2 cells. Recombination produced three alleles, Sema3atm1.1Tyag, Sema3atm1.2Tyag and Sema3atm1.3Tyag. Sema3tm1.1Tyag has had the first exon, including the initiation codon, deleted. (J:43443)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sema3a Mutation:  32 strains or lines available
Homozygous embryos are largely viable after birth but at 4 weeks after birth are about half the body weight of wild-type and have abnormalities in peripheral nerve projection.
Original:  J:43443 Taniguchi M, et al., Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 1997 Sep;19(3):519-30
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory