Foxa2^tm1Dnl
Targeted Allele Detail

Summary

• Symbol: Foxa2^tm1Dnl
• Name: forkhead box A2; targeted mutation 1, James E Darnell
• MGI ID: MGI:2158924
• Synonyms: HNF-3beta -
• Gene: Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
• Alliance: Foxa2^tm1Dnl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19896
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was inserted in-frame just downstream of the translation start site. A neomycin selection cassette was also inserted in reverse transcriptional orientation following the lacZ gene. A beta-galactosidase protein was expresssed from this allele that mimicked the endogenous expression of the gene. (J:19896)

Expression

In Mice Carrying this Mutation:	128 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa2 Mutation: 26 strains or lines available

References

• Original: J:19896 Weinstein DC, et al., The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell. 1994 Aug 26;78(4):575-88
• All: 5 reference(s)