About   Help   FAQ
Targeted Allele Detail
Symbol: Cremtm1Saco
Name: cAMP responsive element modulator; targeted mutation 1, Paolo Sassone-Corsi
MGI ID: MGI:2158921
Synonyms: CREM-
Gene: Crem  Location: Chr18:3266048-3337748 bp, - strand  Genetic Position: Chr18, 2.14 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:31890
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette and an in-frame stop codon between the two alternative DNA-binding domains replaced part of the coding sequence. RNase protection analysis did not detect expression of transcripts in testis from homozygous mutant mice. Western blot analysis did not detect protein in testis from homozygous mutant mice. (J:31890)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crem Mutation:  18 strains or lines available
Original:  J:31890 Nantel F, et al., Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature. 1996 Mar 14;380(6570):159-62
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory