Crem^tm1Saco
Targeted Allele Detail

Summary

• Symbol: Crem^tm1Saco
• Name: cAMP responsive element modulator; targeted mutation 1, Paolo Sassone-Corsi
• MGI ID: MGI:2158921
• Synonyms: CREM-
• Gene: Crem Location: Chr18:3266048-3337748 bp, - strand Genetic Position: Chr18, 2.14 cM, cytoband A
• Alliance: Crem^tm1Saco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31890
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette and an in-frame stop codon between the two alternative DNA-binding domains replaced part of the coding sequence. RNase protection analysis did not detect expression of transcripts in testis from homozygous mutant mice. Western blot analysis did not detect protein in testis from homozygous mutant mice. (J:31890)

Expression

In Mice Carrying this Mutation:	1 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crem Mutation: 38 strains or lines available

References

• Original: J:31890 Nantel F, et al., Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature. 1996 Mar 14;380(6570):159-62
• All: 14 reference(s)