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Cd8b1tm1Wpfl
Targeted Allele Detail
Nomenclature
Symbol: Cd8b1tm1Wpfl
Name: CD8 antigen, beta chain 1; targeted mutation 1, Wai-Ping Fung-Leung
MGI ID: MGI:2158830
Synonyms: CD8beta -
Gene: Cd8b1  Location: Chr6:71322788-71337494 bp, + strand  Genetic Position: Chr6, 32.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19928
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection gene was inserted into exon 1, 7 nucleotides downstream from the translation start site. Flow cytometry experiments on cells derived from thymus, spleen and lymph nodes of homozygous mice confirmed that no protein was expressed from this allele. (J:19928)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8b1 Mutation:  10 strains or lines available
References
Original:  J:19928 Fung-Leung WP, et al., Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. J Exp Med. 1994 Sep 1;180(3):959-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory