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Targeted Allele Detail
Symbol: Thbdtm2Rdr
Name: thrombomodulin; targeted mutation 2, Robert D Rosenberg
MGI ID: MGI:2158818
Synonyms: Thbd-, TMlacZ, TMlacZ, TM-lacZ
Gene: Thbd  Location: Chr2:148246391-148250108 bp, - strand  Genetic Position: Chr2, 73.45 cM
Venous and arterial thrombi and extravascular fibrinogen deposition in the lungs of Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:74855
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ gene and neomycin selection cassette was inserted into the start codon of the gene. A hybrid mRNA molecule, consisting of 157 nucleotides of the endogenous 5' untranslated mRNA followed by the lacZ open reading frame, was transcribed from this allele. (J:71269, J:74855)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  13 strains or lines available
Original:  J:74855 Weiler-Guettler H, et al., Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb;78(2):180-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory