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Ptprstm1Mtr
Targeted Allele Detail
Nomenclature
Symbol: Ptprstm1Mtr
Name: protein tyrosine phosphatase, receptor type, S; targeted mutation 1, Michel L Tremblay
MGI ID: MGI:2158757
Synonyms: Ptprs-, RPTPsigma(-)
Gene: Ptprs  Location: Chr17:56412426-56476480 bp, - strand  Genetic Position: Chr17, 29.32 cM
Craniofacial anomalies in Ptprftm1Wjh/Ptprftm1Wjh Ptprstm1Mtr/Ptprstm1Mtr double-mutant embryos

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53434
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced sequences encoding amino acids 1399-1518 in the intracellular domain, including sequences encoding a conserved CAQYWP motif present in the first PTPase catalytic domain. Northern blot analysis of brain using a probe corresponding to nt 320-1201 of the cDNA sequence did not detect transcript in homozygous mutant newborn mice. Western blot analysis did not detect protein in brain from homozygous mutant newborn mice. (J:53434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprs Mutation:  10 strains or lines available
References
Original:  J:53434 Elchebly M, et al., Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. Nat Genet. 1999 Mar;21(3):330-3
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory