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Casp9tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Casp9tm1Mak
Name: caspase 9; targeted mutation 1, Tak W Mak
MGI ID: MGI:2158754
Gene: Casp9  Location: Chr4:141793612-141815976 bp, + strand  Genetic Position: Chr4, 74.75 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49087
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.6 kb genomic fragment containing three exons was replaced with a neomycin selection cassette. The deleted sequences encode motifs required for protein activity. (J:49087)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp9 Mutation:  7 strains or lines available
References
Original:  J:49087 Hakem R, et al., Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 1998 Aug 7;94(3):339-52
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory