Chrm1^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Chrm1^tm1Stl
• Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:2158743
• Synonyms: M1 -
• Gene: Chrm1 Location: Chr19:8641369-8660970 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Chrm1^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73448
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb genomic fragment containing the entire coding region of the gene was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from forebrain of homozygous mice demonstrated that no detectable transcript was produced from this allele. In situ hybridization analysis on sagittal brain sections of homozygous mice further confirmed that the transcript was not expressed. (J:73448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrm1 Mutation: 26 strains or lines available

References

• Original: J:73448 Gerber DJ, et al., Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15312-7
• All: 8 reference(s)