About   Help   FAQ
Chrna9tm1Bedv
Targeted Allele Detail
Nomenclature
Symbol: Chrna9tm1Bedv
Name: cholinergic receptor, nicotinic, alpha polypeptide 9; targeted mutation 1, Belen Elgoyhen and Douglas E Vetter
MGI ID: MGI:2158742
Synonyms: alpha9-, alpha9 knockout, Chrna9tm1Jbdv
Gene: Chrna9  Location: Chr5:66092264-66134669 bp, + strand  Genetic Position: Chr5, 33.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55406
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 and flanking intronic sequences were replaced with a neomycin selection cassette. The deleted sequences encode the ligand-binding site and the first two transmembrane domains. RT-PCR analysis on nasal epithelium derived from homozygous mice confirmed that no detectable transcript containg sequences from exon 4 is produced from this allele. (J:55406)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna9 Mutation:  42 strains or lines available
References
Original:  J:55406 Vetter DE, et al., Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron. 1999 May;23(1):93-103
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory