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Ptprstm1Dro
Targeted Allele Detail
Nomenclature
Symbol: Ptprstm1Dro
Name: protein tyrosine phosphatase, receptor type, S; targeted mutation 1, Daniela Rotin
MGI ID: MGI:2158734
Synonyms: Ptprs-, PTPsigma-
Gene: Ptprs  Location: Chr17:56412426-56476480 bp, - strand  Genetic Position: Chr17, 29.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53433
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsInsertion of an IRES-beta-galactosidase-neomycin cassette into an intron interrupted the coding sequence between nt 460-850 in the first 1-2 immunoglobulin repeats. Northern analysis using a rat cDNA probe encompassing most of the extracellular domain did not detect transcript in heads of one-day-old homozygous mutant mice. Immunoblot analysis of brain immunoprecipitates using an affinity purified antibody against the intracellular juxtamembrane region did not detect protein in homozygous mutant newborn mice. A beta-galactosidase fusion protein was expressed by this allele under the control of the endogenous promoter. (J:53433)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprs Mutation:  10 strains or lines available
Notes
ES cell line = CJR8.8; strain of origin = 129 (substrain not specified)
References
Original:  J:53433 Wallace MJ, et al., Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Nat Genet. 1999 Mar;21(3):334-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory