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Targeted Allele Detail
Symbol: Tgfbr2tm1Mmt
Name: transforming growth factor, beta receptor II; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:2158728
Gene: Tgfbr2  Location: Chr9:116087695-116175363 bp, - strand  Genetic Position: Chr9, 68.39 cM
Germline Transmission:  Earliest citation of germline transmission: J:73414
Parent Cell Line:  D3a2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 4 at the sequence corresponding to codon 230. RT-PCR analysis on RNA derived from targeted ES cells demonstrated that no wild-type transcript was produced from this allele. (J:73414)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:  7 strains or lines available
Chimeric mice exhibit a wasting phenotype with severe weight loss within 2 weeks. Chimeras show various phenotypes, from small organ size, to cystic kidney and internal hydrcephalus with internal hemorrhage in the brain, or agnathia with anophthalmia and synotia (J:73414).
Original:  J:73414 Oshima M, et al., TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 1996 Oct 10;179(1):297-302
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory