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Chrnb4tm1Mdb
Targeted Allele Detail
Summary
Symbol: Chrnb4tm1Mdb
Name: cholinergic receptor, nicotinic, beta polypeptide 4; targeted mutation 1, Mariella De Biasi
MGI ID: MGI:2158716
Synonyms: beta4 -
Gene: Chrnb4  Location: Chr9:54935438-54956063 bp, - strand  Genetic Position: Chr9, 29.84 cM
Alliance: Chrnb4tm1Mdb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73590
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4.1 kb genomic fragment containing exon 5 was replaced with a puromycin selection gene and an hprt minigene. RT-PCR analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:73590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chrnb4 Mutation:  18 strains or lines available
References
Original:  J:73590 Xu W, et al., Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci. 1999 Nov 1;19(21):9298-305
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory