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Targeted Allele Detail
Symbol: C3ar1tm1Raw
Name: complement component 3a receptor 1; targeted mutation 1, Rick A Wetsel
MGI ID: MGI:2158707
Synonyms: C3aR -
Gene: C3ar1  Location: Chr6:122847140-122856157 bp, - strand  Genetic Position: Chr6, 57.93 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:68807
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsDNA sequences encoding the entire open reading frame of the gene were replaced with a neomycin selection cassette. RT-PCR analysis on RNA derived from brain, kidney, liver, lung, testis and induced peritoneal macrophages demonstrated that no detectable transcript is produced from this allele. Immunocytochemistry and flow cytometry experiments confirmed that no detectable protein is expressed from this allele in induced peritoneal macrophages derived from homozygous mice. (J:68807)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any C3ar1 Mutation:  22 strains or lines available
Original:  J:68807 Kildsgaard J, et al., Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol. 2000 Nov 15;165(10):5406-9
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory