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Targeted Allele Detail
Symbol: C3tm1Hrc
Name: complement component 3; targeted mutation 1, Harvey R Colten
MGI ID: MGI:2158703
Synonyms: C3-
Gene: C3  Location: Chr17:57203970-57228136 bp, - strand  Genetic Position: Chr17, 29.72 cM, cytoband E1-E3
Germline Transmission:  Earliest citation of germline transmission: J:88308
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing 2.3 kb of the 5' flanking region and the first 105 bp of exon 1 was replaced with a neomycin selection cassette. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript was produced in this tissue; however, a full length transcript was detected in lung, kidney, epididymal fat tissue, spleen and heart. (J:56193, J:98856)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any C3 Mutation:  10 strains or lines available
ES cell line = RW4 (129X1/SvJ) or D3 (129S2/SvPas).
Original:  J:88308 Lubinski JM, et al., Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo. J Virol. 1998 Oct;72(10):8257-63
All:  74 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory