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Targeted Allele Detail
Symbol: Npy1rtm1Mnak
Name: neuropeptide Y receptor Y1; targeted mutation 1, Motonao Nakamura
MGI ID: MGI:2158702
Gene: Npy1r  Location: Chr8:66697422-66706798 bp, + strand  Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
Germline Transmission:  Earliest citation of germline transmission: J:51684
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exons 2 and 3 are replaced with a neomycin resistance cassette. Northern blot analysis from brain confirmed the absence of transcript in homozygous mutant animals. The Y5 receptor, which resides in close proximity to the Y1 receptor, was unaffected by the gene targeting, as demonstrated by Northern analysis. (J:51684)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npy1r Mutation:  10 strains or lines available
Original:  J:51684 Kushi A, et al., Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64
All:  1 reference(s)

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MGI 6.06
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