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Npy1rtm1Mnak
Targeted Allele Detail
Nomenclature
Symbol: Npy1rtm1Mnak
Name: neuropeptide Y receptor Y1; targeted mutation 1, Motonao Nakamura
MGI ID: MGI:2158702
Gene: Npy1r  Location: Chr8:66697422-66706798 bp, + strand  Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51684
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exons 2 and 3 are replaced with a neomycin resistance cassette. Northern blot analysis from brain confirmed the absence of transcript in homozygous mutant animals. The Y5 receptor, which resides in close proximity to the Y1 receptor, was unaffected by the gene targeting, as demonstrated by Northern analysis. (J:51684)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npy1r Mutation:  10 strains or lines available
References
Original:  J:51684 Kushi A, et al., Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory