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C1qatm1Mjw
Targeted Allele Detail
Nomenclature
Symbol: C1qatm1Mjw
Name: complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport
MGI ID: MGI:2158701
Synonyms: C1q-, C1qa-
Gene: C1qa  Location: Chr4:136895917-136898803 bp, - strand  Genetic Position: Chr4, 69.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47315
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C1qa Mutation:  6 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Epilepsy (J:159281)

References
Original:  J:47315 Botto M, et al., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [see comments]. Nat Genet. 1998 May;19(1):56-9
All:  94 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory