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Targeted Allele Detail
Symbol: C1qatm1Mjw
Name: complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport
MGI ID: MGI:2158701
Synonyms: C1q-, C1qa-
Gene: C1qa  Location: Chr4:136895917-136898803 bp, - strand  Genetic Position: Chr4, 69.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:47315
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 1 of the gene. Northern blot analysis on samples derived from spleen and liver of homozygous mice demonstrated that no transcript is produced from this allele. Western blot and ELISA analysis confirmed that no protein was detected in samples derived from homozygous mice. (J:47315, J:194445)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C1qa Mutation:  6 strains or lines available
Original:  J:47315 Botto M, et al., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [see comments]. Nat Genet. 1998 May;19(1):56-9
All:  125 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory