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Targeted Allele Detail
Symbol: Scnn1atm1Rss
Name: sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1, Bernard C Rossier
MGI ID: MGI:2158700
Synonyms: alphaENaC -, Scnn1atm1
Gene: Scnn1a  Location: Chr6:125320659-125344943 bp, + strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:31762
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing part of exon 1 and sequences encoding the first transmembrane loop and most of the ectocytoplasmic loop was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from lung, liver and kidney tissue of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:31762)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scnn1a Mutation:  20 strains or lines available
Original:  J:31762 Hummler E, et al., Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 1996 Mar;12(3):325-8
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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