Sox9^tm1Crm
Targeted Allele Detail

Summary

• Symbol: Sox9^tm1Crm
• Name: SRY (sex determining region Y)-box 9; targeted mutation 1, Benoit de Crombrugghe
• MGI ID: MGI:2158693
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^tm1Crm page

Skeletal malformations of Sox9^tm1Crm/Sox9⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69875
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 300 bp DNA fragment containing part of exon 1 was replaced with an IRES-lacZ gene followed by a neomycin selection cassette. Northern blot and western blot analysis on chondrocytes derived from heterozygous mice demonstrated reduced expression of both the encoded transcript and protein. (J:69875, J:75041)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 32 strains or lines available

References

• Original: J:75041 Bi W, et al., Sox9 is required for cartilage formation. Nat Genet. 1999 May;22(1):85-9
• All: 6 reference(s)