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Targeted Allele Detail
Symbol: Sox9tm1Crm
Name: SRY (sex determining region Y)-box 9; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:2158693
Gene: Sox9  Location: Chr11:112782224-112787760 bp, + strand  Genetic Position: Chr11, 77.27 cM
Skeletal malformations of Sox9tm1Crm/Sox9+ mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69875
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 300 bp DNA fragment containing part of exon 1 was replaced with an IRES-lacZ gene followed by a neomycin selection cassette. Northern blot and western blot analysis on chondrocytes derived from heterozygous mice demonstrated reduced expression of both the encoded transcript and protein. (J:69875, J:75041)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  17 strains or lines available
Original:  J:75041 Bi W, et al., Sox9 is required for cartilage formation. Nat Genet. 1999 May;22(1):85-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory